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Open Positions
Research
| Lecturers | Prof. Gaston Gonnet |
| Teaching Assistants |
Nives Skunca Stefan Zoller |
We are in the process of preparing a script for the course. Please contribute to the lecture notes wiki (login using your NETHZ account).
No books are required but much of the material will come from CBRG papers and we will also follow closely some chapters from the book by Dan Gusfield entitled "Algorithms on Strings, Trees, and Sequences". A good reference book for Phylogeny is "Inferring Phylogenies" by Joseph Felsenstein.
If you are interested, you can read this article about DNA for computer scientists
| Week/Date | Topic | Slides | Notes | Exercise | Solution | Lecturer |
| W1 - Sept 21/23 |
Course Introduction; Basic Molecular Biology |
Course Introduction |
UNIX tutorial |
MG / GHG |
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| W2 - Sept 28/30 | Markov Models / String Alignment 1 | Markov Models | Getting started with Darwin | Solutions to questions in darwin intro | GHG | |
| W3 - Oct 5/7 | String Alignment 2 (Indels, Estimating Distances) |
String Alignment Slides, last year Dayhoff paper, 1978 |
Dayhoff Matrix Exercises | Dayhoff Solution | GHG | |
| W4 - Oct 12/14 | Substitution Matrices | What is Dynamic Programming? | Dynamic Programming | DynProg Solution | GHG | |
| W5 - Oct 19/21 | Approx. Alignment; Stat. of Pairwise Alignments | Slides from last year | String alignment in Darwin | Solution to string alignment | MG | |
| W6 - Oct 26/28 | Phylogeny I | Significance of alignments | Solution to significance problems | GHG / MG | ||
| W7 - Nov 2/4 | Phylogeny II | Biorecipe: the Nigerian Prince | MG | |||
| W8 - Nov 9/11 | Phylogeny III | Distance tree exercise | Distance tree, solution | MG | ||
| W9 - Nov 16/18 | Multiple Sequence Alignment | MSA slides | ML tree exercise | ML tree exercise, solution | MG | |
| W10 - Nov 23/25 | Synthetic Evolution; Evaluation of Estimators |
"Evaluation of Methods" slides |
MSA building exercise | ML tree exercise, solution | GHG / MG | |
| W11 - Nov 30, Dec 2 | TBA; Mass Profiling | Synthetic evolution exercise | Solution to synthetic evolution exercise |
Guest / GG |
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| W12 - Dec 7/9 | Orthology/Lateral Gene Transfer | LGT slides | Cake exercise | Solution to cake exercise | GHG/NS | |
| W13 - Dec 14/16 | Codon Bias | Orthology exercise | GHG | |||
| W14 - Dec 21/23 | Genome Rearrangements | GHG |
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