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CBRG - Computational Biochemistry Research Group
 
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Computational Biology (Fall 2010)

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Lecturers Prof. Gaston Gonnet

Dr. Christophe Dessimoz

Teaching Assistants Dr. Manuel Gil
Elke Schaper
Adrian Altenhoff
Adam Szalkowski

Lecture Notes (New!)

We are in the process of preparing a script for the course. Please contribute to the lecture notes wiki (login using your NETHZ account).

Downloads

Books

No books are required but much of the material will come from CBRG papers and we will also follow closely some chapters from the book by Dan Gusfield entitled "Algorithms on Strings, Trees, and Sequences". A good reference book for Phylogeny is "Inferring Phylogenies" by Joseph Felsenstein.

If you are interested, you can read this article about DNA for computer scientists

 

Week/Date Topic Slides Notes Exercise Solution Lecturer
W1 - Sept. 22/23, 2010 Basic Molecular Biology Course Introduction, Central Dogma, Evolution
On the Origin of Eukaryotes Getting started with Darwin   CD
W2 - Sept. 29/30, 2010 String Alignment I Markov Model
Dynamic Programming biorecipe
Dynamic Programming Exercise
GHG
W3 - Oct. 6/7, 2010 String Alignment II - Gap penalties, estimating distances Slides from last year
Prof. Ron Shamir's lecture notes
Darwin Alignments Exercise Darwin Alignments - Solution CD/GHG
W4 - Oct. 13/14, 2010 Substitution Matrices   Unbiased Selection of Sample Alignments biorecipe

Computing Substitution Matrices biorecipe
Dayhoff Matrix Exercise Dayhoff Matrix Solution GHG
W5 - Oct. 20/21, 2010 Approximate Alignment Methods

Statistics of Pairwise Alignments

Statistics of Alignment Scores
Significance assessment of an alignment biorecipe Significance of Alignments and Approximate Search String Exercise Significance of Alignments and Approximate Search String - Solution GHG/CD
W6 - Oct 27/28, 2010 Phylogeny I Overview Trees
Book Chapter Parsimony Tree Exercise and Distance Tree Exercise
  GHG
W7 - Nov 3/4, 2010 Phylogeny II     ML-Tree Exercise ML-Tree Solution
GHG
W8 - Nov. 10/11, 2010 Phylogeny III
    Distance Tree Exercise 2
Distance Tree Solution 2 GHG
W9 - Nov. 17/18, 2010 Multiple Sequence Alignments
MSA Slides
  MSA Scoring Exercise   CD
W10 - Nov. 24, 2010 Synthetic evolution
  Synthetic Evolution notes MSA Building Exercise
MSA Building Exercise Solution
GHG
W10 - Nov 25, 2010
Invited speakers:
Dr. Martin Ebeling (Roche)
Dr. Manuel Gil (ETH Zurich)

         
W11 - Dec 1, 2010 Invited speaker:

Dr. Nick Goldman (European Bioinformatics Institute)

 
     
W11 - Dec 2, 2010
Searching a database using Mass spec weights and   Mass Spec biorecipe Cake Exercise Cake - Solution GHG
W12 - Dec. 8/9, 2010 Orthology Slides
Finding Orthologous Sequences biorecipe Orthologs Exercise Orthologs Solution CD
W13 - Dec. 15/16, 2010 Codons, codons, codons   Codon Bias biorecipe Synthetic Evolution Exercise Synthetic Evolution - Solution
GHG
W14 - Dec. 22/23, 2010 Genome Rearrangements & Alignment
Slides
  no Exercise   GHG

CD

 

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