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CBRG - Computational Biochemistry Research Group
 
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Computational Biology (Fall 2011)

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Lecture Notes (New!)

We are in the process of preparing a script for the course. Please contribute to the lecture notes wiki (login using your NETHZ account).

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Books

No books are required but much of the material will come from CBRG papers and we will also follow closely some chapters from the book by Dan Gusfield entitled "Algorithms on Strings, Trees, and Sequences". A good reference book for Phylogeny is "Inferring Phylogenies" by Joseph Felsenstein.

If you are interested, you can read this article about DNA for computer scientists

 

Week/Date Topic Slides Notes Exercise Solution Lecturer
W1 - Sept 21/23 Course Introduction; Basic Molecular Biology

Course Introduction
  UNIX tutorial   MG / GHG
W2 - Sept 28/30 Markov Models / String Alignment 1 Markov Models   Getting started with Darwin Solutions to questions in darwin intro GHG
W3 - Oct 5/7 String Alignment 2 (Indels, Estimating Distances)   String Alignment Slides, last year

Dayhoff paper, 1978
Dayhoff Matrix Exercises Dayhoff Solution GHG
W4 - Oct 12/14 Substitution Matrices   What is Dynamic Programming? Dynamic Programming DynProg Solution GHG
W5 - Oct 19/21 Approx. Alignment; Stat. of Pairwise Alignments   Slides from last year String alignment in Darwin Solution to string alignment MG
W6 - Oct 26/28 Phylogeny I     Significance of alignments Solution to significance problems GHG / MG
W7 - Nov 2/4 Phylogeny II     Biorecipe: the Nigerian Prince   MG
W8 - Nov 9/11 Phylogeny III     Distance tree exercise Distance tree, solution MG
W9 - Nov 16/18 Multiple Sequence Alignment MSA slides   ML tree exercise ML tree exercise, solution MG
W10 - Nov 23/25 Synthetic Evolution; Evaluation of Estimators "Evaluation of Methods" slides
  MSA building exercise ML tree exercise, solution GHG / MG
W11 - Nov 30, Dec 2 TBA; Mass Profiling     Synthetic evolution exercise Solution to synthetic evolution exercise Guest / GG
W12 - Dec 7/9 Orthology/Lateral Gene Transfer LGT slides   Cake exercise Solution to cake exercise GHG/NS
W13 - Dec 14/16 Codon Bias     Orthology exercise   GHG
W14 - Dec 21/23 Genome Rearrangements         GHG
 

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© 2012 ETH Zurich | Imprint | Disclaimer | 14 December 2011
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